Gut Microbiota Orchestrates Energy Homeostasis during Cold.
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IF: 66.850
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Cited by: 499
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Abstract

Microbial functions in the host physiology are a result of the microbiota-host co-evolution. We show that cold exposure leads to marked shift of the microbiota composition, referred to as cold microbiota. Transplantation of the cold microbiota to germ-free mice is sufficient to increase insulin sensitivity of the host and enable tolerance to cold partly by promoting the white fat browning, leading to increased energy expenditure and fat loss. During prolonged cold, however, the body weight loss is attenuated, caused by adaptive mechanisms maximizing caloric uptake and increasing intestinal, villi, and microvilli lengths. This increased absorptive surface is transferable with the cold microbiota, leading to altered intestinal gene expression promoting tissue remodeling and suppression of apoptosis-the effect diminished by co-transplanting the most cold-downregulated strain Akkermansia muciniphila during the cold microbiota transfer. Our results demonstrate the microbiota as a key factor orchestrating the overall energy homeostasis during increased demand.

Keywords

PROCEDURE
Gene Expression

MeSH terms

Adipose Tissue, White
Animals
Apoptosis
Cold Temperature
Energy Metabolism
Enterocytes
Gastrointestinal Microbiome
Gastrointestinal Tract
Germ-Free Life
Homeostasis
Insulin Resistance
Intestinal Absorption
Mice
Verrucomicrobia

Authors

Chevalier, Claire
Stojanović, Ozren
Colin, Didier J
Suarez-Zamorano, Nicolas
Tarallo, Valentina
Veyrat-Durebex, Christelle
Rigo, Dorothée
Fabbiano, Salvatore
Stevanović, Ana
Hagemann, Stefanie
Montet, Xavier
Seimbille, Yann
Zamboni, Nicola
Hapfelmeier, Siegfried
Trajkovski, Mirko

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