Spatiotemporal transcriptomic atlas of hypothalamus across lifespan(Dataset ID: STDS0000382)

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Summary
Visualization
Data
Sample
Catalog
Dataset information
Contributors
Accessions
How to cite
Dataset information
Summary:
The Hypothalamus Comprehensive Database is a multi-species developmental and adult database covering human, macaque and mouse, integrating single cell transcriptome, single cell epigenome and single cell spatialome. The database covers development, evolution, disease and ageing, providing a systematic reference database for the hypothalamus field.
Overall design:
We collected mouse hypothalamus during E11.5, E14.5, P0, P7, P14, P30 for single-cell/nucles transcriptome and single-nucles epigenome sequencing; We collected non-human primate macaque hypothalamus tissue at PCW5, PCW8, PCW11 for single-cell transcriptome sequencing; We collected human embryonic hypothalamus at PCW5, PCW6, PCW7, PCW9, PCW10, PCW12, PCW13, PCW16, PCW20 were collected for single-cell/nucles transcriptome and epigenome sequencing. We collected mouse hypothalamus during E11.5, E13.5, E15.5, P0, P7 for single cell spatial transcriptome sequencing.
Platform:
DNBSEQ-T7 | Illumina HiSeq | DIPSEQ-T1
Species:
Homo sapiens
Mus musculus
Macaca mulatta
Tissues:
Brain
Submission date: 2025-07-15Update date: 2025-07-15
Sample number: 12Section number: 12
DOI: To be continue
Contributors
Qing-Feng Wu | Zhen-Hua Chen | Tao-Tao Pan | Meixi Gao | Yang Sun | Ming-Rui Xu ...
Accessions
No results.
How to cite
  • Cite database of STOmicsDB:
    [1] Xu, Zhicheng et al. "STOmicsDB: a comprehensive database for spatial transcriptomics data sharing, analysis and visualization." Nucleic acids research vol. 52,D1 (2024): D1053-D1061. doi: 10.1093/nar/gkad933'
  • Cite visualization dataset:
    [2] Qing-Feng Wu | Zhen-Hua Chen | Tao-Tao Pan | Meixi Gao | Yang Sun | Ming-Rui Xu .... Spatiotemporal transcriptomic atlas of hypothalamus across lifespan[DS/OL]. STOmicsDB, 2025[2025-07-15]. https://db.cngb.org/stomics/datasets/STDS0000382/. doi: xxxxxx
    #Format: {contributors}. {title}[DS/OL]. STOmicsDB, {the year of submission data}[{submission data}]. {dataset link}. doi: {doi ID}
  • Cite original data article:
    Citation: 1. Steuernagel L, Lam BYH, Klemm P, Dowsett GKC, Bauder CA, Tadross JA, Hitschfeld TS, Del Rio Martin A, Chen W, de Solis AJ, Fenselau H, Davidsen P, Cimino I, Kohnke SN, Rimmington D, Coll AP, Beyer A, Yeo GSH, Brüning JC. HypoMap-a unified single-cell gene expression atlas of the murine hypothalamus. Nat Metab. 2022 Oct;4(10):1402-1419. doi: 10.1038/s42255-022-00657-y. Epub 2022 Oct 20. PMID: 36266547; PMCID: PMC9584816.2. Chen ZH, Li S, Xu M, Liu CC, Ye H, Wang B, Wu QF. Single-cell transcrip