Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing plasma cells in renal cell cancer(Dataset ID: STDS0000223)

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PMID: 35231421 (IF:32.4 Q1)
Summary
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Dataset information
Summary:
The presence of intratumoral tertiary lymphoid structures (TLS) is associated with positive clinical outcomes and responses to immunotherapy in cancer. Here, we used spatial transcriptomics to examine the nature of B cell responses within TLS in renal cell carcinoma (RCC). B cells were enriched in TLS, and therein, we could identify all B cell maturation stages toward plasma cell (PC) formation. B cell repertoire analysis revealed clonal diversification, selection, expansion in TLS, and the presence of fully mature clonotypes at distance. In TLS+ tumors, IgG- and IgA-producing PCs disseminated into the tumor beds along fibroblastic tracks. TLS+ tumors exhibited high frequencies of IgG-producing PCs and IgG-stained and apoptotic malignant cells, suggestive of anti-tumor effector activity. Therapeutic responses and progression-free survival correlated with IgG-stained tumor cells in RCC patients treated with immune checkpoint inhibitors. Thus, intratumoral TLS sustains B cell maturation and antibody production that is associated with response to immunotherapy, potentially via direct anti-tumor effects.
Overall design:
Spatial transcriptomics of fresh frozen ccRCC human tumors *** Raw data has not been submitted at this time due to patient privacy concerns ***
Technology:
10x Visium
Platform:
Illumina NovaSeq 6000
Species:
Homo sapiens(hg38)
Tissues:
Kidney
Organ parts:
ccRCC tumor
Disease:
renal cell cancer
Submission date: 2021-05-25Update date: 2022-04-19
Sample number: 24Section number: 24
DOI: To be continue
Contributors
Meylan, Maxime,de Reyniès, Aurélien,Sautès-Fridman, Catherine,Fridman, Wolf H
Accessions
GEO Series Accessions: GSE175540
How to cite
  • Cite database of STOmicsDB:
    [1] Xu, Zhicheng et al. "STOmicsDB: a comprehensive database for spatial transcriptomics data sharing, analysis and visualization." Nucleic acids research vol. 52,D1 (2024): D1053-D1061. doi: 10.1093/nar/gkad933'
  • Cite visualization dataset:
    [2] Meylan, Maxime,de Reyniès, Aurélien,Sautès-Fridman, Catherine,Fridman, Wolf H. Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing plasma cells in renal cell cancer[DS/OL]. STOmicsDB, 2021[2021-05-25]. https://db.cngb.org/stomics/datasets/STDS0000223/. doi: xxxxxx
    #Format: {contributors}. {title}[DS/OL]. STOmicsDB, {the year of submission data}[{submission data}]. {dataset link}. doi: {doi ID}
  • Cite original data article:
    Citation: Meylan, Maxime et al. “Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing plasma cells in renal cell cancer.” Immunity vol. 55,3 (2022): 527-541.e5. doi:10.1016/j.immuni.2022.02.001