Cellular Dialogues: Cell-Cell Communication through Diffusible Molecules Yields Dynamic Spatial Patterns.
IF: 11.091
Cited by: 7


Cells form spatial patterns by coordinating their gene expressions. How a group of mesoscopic numbers (hundreds to thousands) of cells, without pre-existing morphogen gradients and spatial organization, self-organizes spatial patterns remains poorly understood. Of particular importance are dynamic spatial patterns such as spiral waves that perpetually move and transmit information. We developed an open-source software for simulating a field of cells that communicate by secreting any number of molecules. With this software and a theory, we identified all possible "cellular dialogues"-ways of communicating with two diffusing molecules-that yield diverse dynamic spatial patterns. These patterns emerge despite widely varying responses of cells to the molecules, gene-expression noise, spatial arrangements, and cell movements. A three-stage, "order-fluctuate-settle" process forms dynamic spatial patterns: cells form long-lived whirlpools of wavelets that, following erratic dynamics, settle into a dynamic spatial pattern. Our work helps in identifying gene-regulatory networks that underlie dynamic pattern formations.


Spatial Gene Expression
cell-cell communication
cellular automata
complex systems
gene networks
multicellular systems
pattern formation
self organization
spatial patterns

MeSH terms

Cell Communication
Gene Regulatory Networks
Models, Biological


Dang, Yiteng
Grundel, Douwe A J
Youk, Hyun

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