The Human Cell Atlas.
IF: 8.713
Cited by: 985


The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in the human body. The Human Cell Atlas Project is an international collaborative effort that aims to define all human cell types in terms of distinctive molecular profiles (such as gene expression profiles) and to connect this information with classical cellular descriptions (such as location and morphology). An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular dysregulation in human disease. Here we describe the idea, its potential utility, early proofs-of-concept, and some design considerations for the Human Cell Atlas, including a commitment to open data, code, and community.


Gene Expression
cell atlas
cell biology
computational biology
science forum
single-cell genomics
systems biology

MeSH terms

Atlases as Topic
Eukaryotic Cells
Human Body
International Cooperation


Regev, Aviv
Teichmann, Sarah A
Lander, Eric S
Amit, Ido
Benoist, Christophe
Birney, Ewan
Bodenmiller, Bernd
Campbell, Peter
Carninci, Piero
Clatworthy, Menna
Clevers, Hans
Deplancke, Bart
Dunham, Ian
Eberwine, James
Eils, Roland
Enard, Wolfgang
Farmer, Andrew
Fugger, Lars
Göttgens, Berthold
Hacohen, Nir
Haniffa, Muzlifah
Hemberg, Martin
Kim, Seung
Klenerman, Paul
Kriegstein, Arnold
Lein, Ed
Linnarsson, Sten
Lundberg, Emma
Lundeberg, Joakim
Majumder, Partha
Marioni, John C
Merad, Miriam
Mhlanga, Musa
Nawijn, Martijn
Netea, Mihai
Nolan, Garry
Pe'er, Dana
Phillipakis, Anthony
Ponting, Chris P
Quake, Stephen
Reik, Wolf
Rozenblatt-Rosen, Orit
Sanes, Joshua
Satija, Rahul
Schumacher, Ton N
Shalek, Alex
Shapiro, Ehud
Sharma, Padmanee
Shin, Jay W
Stegle, Oliver
Stratton, Michael
Stubbington, Michael J T
Theis, Fabian J
Uhlen, Matthias
van Oudenaarden, Alexander
Wagner, Allon
Watt, Fiona
Weissman, Jonathan
Wold, Barbara
Xavier, Ramnik
Yosef, Nir

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