PMID- 29206104 OWN - NLM STAT- MEDLINE VI - 6 TI - The Human Cell Atlas. LA - eng PT - Journal Article PL - England TA - Elife JT - eLife JID - 101579614 IS - 2050-084X (Electronic) LID - 10.7554/eLife.27041 [doi] LID - e27041 [pii] FAU - Regev, Aviv AU - Regev A AUID- ORCID: 0000-0003-3293-3158 AD - Broad Institute of MIT and Harvard, Cambridge, United States. AD - Department of Biology, Massachusetts Institute of Technology, Cambridge, United States. AD - Howard Hughes Medical Institute, Chevy Chase, United States. FAU - Teichmann, Sarah A AU - Teichmann SA AD - Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom. AD - EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom. AD - Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge, United Kingdom. FAU - Lander, Eric S AU - Lander ES AD - Broad Institute of MIT and Harvard, Cambridge, United States. AD - Department of Biology, Massachusetts Institute of Technology, Cambridge, United States. AD - Department of Systems Biology, Harvard Medical School, Boston, United States. FAU - Amit, Ido AU - Amit I AD - Department of Immunology, Weizmann Institute of Science, Rehovot, Israel. FAU - Benoist, Christophe AU - Benoist C AD - Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, United States. FAU - Birney, Ewan AU - Birney E AD - EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom. FAU - Bodenmiller, Bernd AU - Bodenmiller B AD - EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom. AD - Institute of Molecular Life Sciences, University of Zürich, Zürich, Switzerland. FAU - Campbell, Peter AU - Campbell P AD - Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom. AD - Department of Haematology, University of Cambridge, Cambridge, United Kingdom. FAU - Carninci, Piero AU - Carninci P AUID- ORCID: 0000-0001-7202-7243 AD - Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge, United Kingdom. AD - Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Japan. FAU - Clatworthy, Menna AU - Clatworthy M AD - Molecular Immunity Unit, Department of Medicine, MRC Laboratory of Molecular Biology, University of Cambridge, Cambridge, United Kingdom. FAU - Clevers, Hans AU - Clevers H AD - Hubrecht Institute, Princess Maxima Center for Pediatric Oncology and University Medical Center Utrecht, Utrecht, The Netherlands. FAU - Deplancke, Bart AU - Deplancke B AUID- ORCID: 0000-0001-9935-843X AD - Institute of Bioengineering, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland. FAU - Dunham, Ian AU - Dunham I AD - EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom. FAU - Eberwine, James AU - Eberwine J AD - Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States. FAU - Eils, Roland AU - Eils R AD - Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany. AD - Department for Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant, Heidelberg University, Heidelberg, Germany. FAU - Enard, Wolfgang AU - Enard W AUID- ORCID: 0000-0002-4056-0550 AD - Department of Biology II, Ludwig Maximilian University Munich, Martinsried, Germany. FAU - Farmer, Andrew AU - Farmer A AD - Takara Bio United States, Inc., Mountain View, United States. FAU - Fugger, Lars AU - Fugger L AD - Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, and MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom. FAU - Göttgens, Berthold AU - Göttgens B AUID- ORCID: 0000-0001-6302-5705 AD - Department of Haematology, University of Cambridge, Cambridge, United Kingdom. AD - Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom. FAU - Hacohen, Nir AU - Hacohen N AD - Broad Institute of MIT and Harvard, Cambridge, United States. AD - Massachusetts General Hospital Cancer Center, Boston, United States. FAU - Haniffa, Muzlifah AU - Haniffa M AUID- ORCID: 0000-0002-3927-2084 AD - Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom. FAU - Hemberg, Martin AU - Hemberg M AD - Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom. FAU - Kim, Seung AU - Kim S AD - Departments of Developmental Biology and of Medicine, Stanford University School of Medicine, Stanford, United States. FAU - Klenerman, Paul AU - Klenerman P AD - Peter Medawar Building for Pathogen Research and the Translational Gastroenterology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom. AD - Oxford NIHR Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom. FAU - Kriegstein, Arnold AU - Kriegstein A AD - Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, United States. FAU - Lein, Ed AU - Lein E AUID- ORCID: 0000-0001-9012-6552 AD - Allen Institute for Brain Science, Seattle, United States. FAU - Linnarsson, Sten AU - Linnarsson S AD - Laboratory for Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. FAU - Lundberg, Emma AU - Lundberg E AD - Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, Stockholm, Sweden. AD - Department of Genetics, Stanford University, Stanford, United States. FAU - Lundeberg, Joakim AU - Lundeberg J AD - Science for Life Laboratory, Department of Gene Technology, KTH Royal Institute of Technology, Stockholm, Sweden. FAU - Majumder, Partha AU - Majumder P AD - National Institute of Biomedical Genomics, Kalyani, India. FAU - Marioni, John C AU - Marioni JC AD - Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom. AD - EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom. AD - Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom. FAU - Merad, Miriam AU - Merad M AD - Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, United States. FAU - Mhlanga, Musa AU - Mhlanga M AD - Division of Chemical, Systems & Synthetic Biology, Institute for Infectious Disease & Molecular Medicine (IDM), Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa. FAU - Nawijn, Martijn AU - Nawijn M AD - Department of Pathology and Medical Biology, GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. FAU - Netea, Mihai AU - Netea M AD - Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands. FAU - Nolan, Garry AU - Nolan G AD - Department of Microbiology and Immunology, Stanford University, Stanford, United States. FAU - Pe'er, Dana AU - Pe'er D AD - Computational and Systems Biology Program, Sloan Kettering Institute, New York, United States. FAU - Phillipakis, Anthony AU - Phillipakis A AD - Broad Institute of MIT and Harvard, Cambridge, United States. FAU - Ponting, Chris P AU - Ponting CP AUID- ORCID: 0000-0003-0202-7816 AD - MRC Human Genetics Unit, MRC Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom. FAU - Quake, Stephen AU - Quake S AD - Department of Applied Physics and Department of Bioengineering, Stanford University, Stanford, United States. AD - Chan Zuckerberg Biohub, San Francisco, United States. FAU - Reik, Wolf AU - Reik W AD - Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom. AD - Epigenetics Programme, The Babraham Institute, Cambridge, United Kingdom. AD - Centre for Trophoblast Research, University of Cambridge, Cambridge, United Kingdom. FAU - Rozenblatt-Rosen, Orit AU - Rozenblatt-Rosen O AD - Broad Institute of MIT and Harvard, Cambridge, United States. FAU - Sanes, Joshua AU - Sanes J AUID- ORCID: 0000-0001-8926-8836 AD - Center for Brain Science and Department of Molecular and Cellular Biology, Harvard University, Cambridge, United States. FAU - Satija, Rahul AU - Satija R AUID- ORCID: 0000-0001-9448-8833 AD - Department of Biology, New York University, New York, United States. AD - New York Genome Center, New York University, New York, United States. FAU - Schumacher, Ton N AU - Schumacher TN AD - Division of Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. FAU - Shalek, Alex AU - Shalek A AD - Broad Institute of MIT and Harvard, Cambridge, United States. AD - Institute for Medical Engineering & Science (IMES) and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, United States. AD - Ragon Institute of MGH, MIT and Harvard, Cambridge, United States. FAU - Shapiro, Ehud AU - Shapiro E AD - Department of Computer Science and Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel. FAU - Sharma, Padmanee AU - Sharma P AD - Department of Genitourinary Medical Oncology, Department of Immunology, MD Anderson Cancer Center, University of Texas, Houston, United States. FAU - Shin, Jay W AU - Shin JW AD - Division of Genomic Technologies, RIKEN Center for Life Science Technologies, Yokohama, Japan. FAU - Stegle, Oliver AU - Stegle O AD - EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom. FAU - Stratton, Michael AU - Stratton M AD - Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom. FAU - Stubbington, Michael J T AU - Stubbington MJT AD - Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom. FAU - Theis, Fabian J AU - Theis FJ AD - Institute of Computational Biology, German Research Center for Environmental Health, Helmholtz Center Munich, Neuherberg, Germany. AD - Department of Mathematics, Technical University of Munich, Garching, Germany. FAU - Uhlen, Matthias AU - Uhlen M AD - Science for Life Laboratory and Department of Proteomics, KTH Royal Institute of Technology, Stockholm, Sweden. AD - Novo Nordisk Foundation Center for Biosustainability, Danish Technical University, Lyngby, Denmark. FAU - van Oudenaarden, Alexander AU - van Oudenaarden A AD - Hubrecht Institute and University Medical Center Utrecht, Utrecht, The Netherlands. FAU - Wagner, Allon AU - Wagner A AD - Department of Electrical Engineering and Computer Science and the Center for Computational Biology, University of California, Berkeley, Berkeley, United States. FAU - Watt, Fiona AU - Watt F AUID- ORCID: 0000-0001-9151-5154 AD - Centre for Stem Cells and Regenerative Medicine, King's College London, London, United Kingdom. FAU - Weissman, Jonathan AU - Weissman J AUID- ORCID: 0000-0003-2445-670X AD - Howard Hughes Medical Institute, Chevy Chase, United States. AD - Department of Cellular & Molecular Pharmacology, University of California, San Francisco, San Francisco, United States. AD - California Institute for Quantitative Biomedical Research, University of California, San Francisco, San Francisco, United States. AD - Center for RNA Systems Biology, University of California, San Francisco, San Francisco, United States. FAU - Wold, Barbara AU - Wold B AD - Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States. FAU - Xavier, Ramnik AU - Xavier R AD - Broad Institute of MIT and Harvard, Cambridge, United States. AD - Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, United States. AD - Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, United States. AD - Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, United States. FAU - Yosef, Nir AU - Yosef N AUID- ORCID: 0000-0001-9004-1225 AD - Ragon Institute of MGH, MIT and Harvard, Cambridge, United States. AD - Department of Electrical Engineering and Computer Science and the Center for Computational Biology, University of California, Berkeley, Berkeley, United States. CN - Human Cell Atlas Meeting Participants IS - 2050-084X (Linking) SB - IM MH - *Atlases as Topic MH - Eukaryotic Cells/*classification/*physiology MH - *Human Body MH - Humans MH - International Cooperation OTO - NOTNLM OT - cell atlas OT - cell biology OT - computational biology OT - human OT - lineage OT - mouse OT - science forum OT - single-cell genomics OT - systems biology PMC - PMC5762154 DCOM- 20180822 LR - 20240210 DP - 20171205 DEP - 20171205 AB - The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in the human body. The Human Cell Atlas Project is an international collaborative effort that aims to define all human cell types in terms of distinctive molecular profiles (such as gene expression profiles) and to connect this information with classical cellular descriptions (such as location and morphology). An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular dysregulation in human disease. Here we describe the idea, its potential utility, early proofs-of-concept, and some design considerations for the Human Cell Atlas, including a commitment to open data, code, and community.