Temporal and spatial expression of Muc1 during implantation in sows.

PMID:20640155

IF: 6.208

Cited by: 17

Abstract

Recent evidence points to an important role for Muc1 in embryo implantation. In this study, Real-time PCR and immunohistochemistry were used to study mRNA and protein levels at, and between, the attachment sites of the endometrium of Day 13, 18 and 24 pregnant sows. The results indicate that Muc1 mRNA expression was higher between attachment sites than at attachment sites during implantation and this effect was significant on Day 13 (P < 0.01) and 24 (P < 0.01). Intense Muc1 immunostaining was observed in luminal epithelium and stroma and the staining between attachment sites was stronger than at attachment sites on Days 13 and 18. Collectively, these results suggest the crucial role of Muc1 in successful implantation and embryo survival.

Keywords

Spatial Gene Expression

endometrium

expression

implantation

muc1

sows

MeSH terms

Animals

Embryo Implantation

Endometrium

Female

Gene Expression Regulation, Developmental

Immunohistochemistry

Mucin-1

Organ Specificity

Pregnancy

Real-Time Polymerase Chain Reaction

Swine

Time Factors

Authors

Ren, Qian

Guan, Shu

Fu, Jinluan

Wang, Aiguo

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