Cross-species single-cell and spatial transcriptomic maps of the spleen reveal the origin and evolution of the GC-like module
IDSTT0000158(Source: STOmics DB)
STOmics technology:BGI Stereomics Stereo-Seq
Organism(s):
Chiloscyllium plagiosum
,Protopterus annectens
Data type:Spatial transcriptomics
Sample scope:Multispecies
Summary:Germinal center (GC) is the core microstructure of mammalian adaptive immunity, but the evolutionary origins and functional precursors in ectothermic vertebrates is still unclear. Here we systematically reconstruct the evolutionary trajectory of GC-like structures by integrating spleen single-cell and spatial transcriptomic data across six major jawed vertebrate classes (from chondrichthyans to mammals).
Contributor(s):Xiang Liu, Yingyi Huang, Yanan Li, Lidong Guo, Sheng Du et al.
Publication(s):
  • Xiang Liu, Yingyi Huang, Yanan Li, Lidong Guo, Sheng Du et al. Cross-species single-cell and spatial transcriptomic maps of the spleen reveal the origin and evolution of the GC-like module.
Submitter:李亚楠(Yanan Li),Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences
Release date:2025-11-30
Updated:2025-11-30
Statistics:
  • Sample: 2
  • Tissue Section: 2
  • Experiment: 2
  • Run: 2
Datasize:516.34GB
Sequencing Data
Spatial Gene Expression
ProjectSampleTissue SectionExperimentRunOrganismPlatformSequencing readsMask file