STOmics technology:BGI Stereomics Stereo-Seq

Data type:Spatial transcriptomics

Sample scope:Multiisolate

Summary:The manuscript investigates the role of double-positive (DP) thymocytes in sepsis-induced thymic atrophy and subsequent recovery. Sepsis, a life-threatening condition caused by the body's response to an infection, can lead to a dramatic shrinkage of the thymus, which is crucial for T cell development and maintaining a diverse T cell receptor repertoire. The study utilizes single-cell and spatial analysis to explore the molecular mechanisms underlying thymic atrophy and regeneration. Key findings include the identification of distinct DP thymocyte subpopulations, such as DPrea, that are responsible for acute thymic atrophy and recovery. The research also provides insights into the differential gene expression patterns during the process, highlighting changes in apoptosis-related genes and the dynamics of CD4+ and CD8+ single-positive (SP) thymocytes. These results contribute to a better understanding of how the thymus responds to sepsis and recovers, potentially informing new therapeutic approaches for immune reconstitution following severe infections

Contributor(s):Xiaofeng Shi, Haohao Deng, Panyu Zhang, Chenlu Yang, Ziqing Deng et al.

Submitter:张盼玉(PanyuZhang),BGI

Release date:2026-10-08

Updated:2026-10-08