Spatiotemporal transcriptomic maps of mouse intracerebral hemorrhage at single-cell resolution
IDSTT0000047(Source: STOmics DB)
STOmics technology:BGI Stereomics Stereo-Seq
Organism(s):
Mus musculus
Data type:Spatial transcriptomics
Sample scope:Monoisolate
Summary:Intracerebral hemorrhage (ICH) is a prevalent disease with high mortality. Despite advances in clinical care, the prognosis of ICH remains poor due to an incomplete understanding of the complex pathological processes. To address this challenge, we generated single-cell resolution spatiotemporal transcriptomic maps of mouse brain after ICH. This data set is the most extended resource available that provides detailed information about temporal expression of genes together with a high resolution cellular profile and preserved cellular organization. We identified 100 distinct cellular subclasses, 17 of which were found to play significant roles in the pathophysiology of ICH. We also report similarities and differences between two experimental ICH models and human postmortem ICH brain tissue. This study advances the understanding of the local and global responses of brain cells to ICH, and provides a valuable resource that can facilitate future research and aid the development of novel therapies for this devastating condition.
Contributor(s):Wang Jian.
Publication(s):
  • Rong Xiang, Junming Wang, Zhan Chen, Jin Tao, Qinfeng Peng et al. Spatiotemporal transcriptomic maps of mouse intracerebral hemorrhage at single-cell resolution.
Submitter:陈展,华大研究院
Release date:2025-04-12
Updated:2025-05-14
Statistics:
  • Sample: 6
  • Tissue Section: 29
Datasize:37.12GB
Spatial Gene Expression
ProjectSampleTissue SectionOrganismFiles