1Spatial transcriptomics combined with sc RNA sequencing reveals pathogenic mechanisms in lupus erythematosus skin lesionsSource: STOmics DB (ID: STT0000149 )

Lupus, a severe and complex autoimmune disease, is clinically divided into cutaneous lupus erythematosus (CLE) which featured in skin damage, and systemic lupus erythematosus (SLE) which characterized in systemic multi-organ damage. However, the characteristics and distinctions of the immune microenvironment in lesions of DLE and SLE patients has not been fully understood. Here, we performed spatial transcriptomic sequencing (Stereo-seq) to characterize cellular infiltration and crosstalk in 15 skin biopsies of healthy control(HC), DLE, and SLE, which providing a comprehensive in-depth knowledge of the nature of lupus skin lesions to guide the development of better treatments.