Spatial transcriptomics combined with sc RNA sequencing reveals pathogenic mechanisms in lupus erythematosus skin lesions
IDSTT0000149(Source: STOmics DB)
STOmics technology:BGI Stereomics Stereo-Seq
Organism(s):
Data type:Spatial transcriptomics
Sample scope:Monoisolate
Summary:Lupus, a severe and complex autoimmune disease, is clinically divided into cutaneous lupus erythematosus (CLE) which featured in skin damage, and systemic lupus erythematosus (SLE) which characterized in systemic multi-organ damage. However, the characteristics and distinctions of the immune microenvironment in lesions of DLE and SLE patients has not been fully understood. Here, we performed spatial transcriptomic sequencing (Stereo-seq) to characterize cellular infiltration and crosstalk in 15 skin biopsies of healthy control(HC), DLE, and SLE, which providing a comprehensive in-depth knowledge of the nature of lupus skin lesions to guide the development of better treatments.
Contributor(s):Huang Yufen.
Publication(s):
- Huang Yufen. Spatial transcriptomics combined with sc RNA sequencing reveals pathogenic mechanisms in lupus erythematosus skin lesions.
Submitter:黄玉芬,BGI
Release date:2026-02-12
Updated:2026-02-12
Statistics:
- Sample: 15
- Tissue Section: 15
Datasize:24.6GB
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