ABSTA：Amniotes Brain Spatiotemporal Transcriptomic Atlas(Dataset ID: STDS0000241)
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Summary:
The evolution of amniotes introduced the emergence of intricate brain organization, particularly in the telencephalon, but its genoarchitectonic identity and evolutionary trajectory remain unclear. By constructing spatial transcriptomic atlases of the zebra finch and turtle telencephalon, we enable unparalleled comparisons among sauropsids (reptiles and birds), allowing us to decode the evolutionary origins of the complex DVR subregions in sauropsids. Notably, we elucidated the molecular mechanism by which the avian DVR and mammalian neocortex recruit the same effector genes via divergent transcription factors, underscoring their functional convergent evolution. Collectively, our data shed light on the nuanced evolutionary relationships within the telencephalon among amniotes, providing a new fundamental understanding of brain evolution.Overall design:
ATSTA database has coronal sections of brains from three amniotes, including Chinese softshell turtles (Pelodiscus sinensis), zebra finches (Taeniopygia guttata), and mouse(mus musculus) using Stereo-seq. In the ATSTA, we provide the spatial map showing the 'genoarchitecture' of brain, and gene expression in each species coronal sections. Our panoramic atlas will allow in-depth investigation of longstanding questions concerning amniotes evolution.Technology:
Stereo-Seq
Tissues:
Brain
Submission date: 2024-04-17Update date: 2024-04-17
Sample number: 3Section number: 8
Contributors
Zhenkun Zhuang; Fubaoqian Huang; Kuo Liao; Youning Lin; Duoyuan Chen; Hong wang; Jinfeng Huang; Chengyu Li; Zhenlong Wang; Xun Xu; Robert K. Naumann; Shiping Liu
Contact: zhuangzhenkun@genomic.cn
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