Computational cell-cell interaction technologies drive mechanistic and biomarker discovery in the tumor microenvironment.
IF: 10.279


Complex networks of cell-cell interactions (CCIs) within the tumor microenvironment (TME) play a crucial role in cancer persistence. These communication axes represent prime targets for therapeutic intervention, but our incomplete understanding of the cellular heterogeneity and interacting partners within the TME remains a stubborn barrier to complete drug responses. This review outlines recent advances in the study of CCIs that leverage single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) technologies that can clarify TME dynamics. We anticipate that these strategies will promote discovery of CCIs critical to the tumor-immune interface and will, by extension, expand the repertoire of druggable tumor biomarkers.


Spatial Transcriptomics

MeSH terms

Tumor Microenvironment
Biomedical Research
Cell Communication
Single-Cell Analysis


Pong, Avery
Mah, Clarence K
Yeo, Gene W
Lewis, Nathan E