Multicellular dynamics of zonal liver regeneration mapped in space and time.
Abstract
In this issue, Ben-Moshe et al. (2022) use spatiotemporally resolved single-cell and spatial transcriptomic profiling to dissect the multicellular dynamics enabling zonal liver regeneration. They highlight how pan-zonal compensatory hepatocyte proliferation, transient reprogramming of peri-injury hepatocytes, and concerted zonated action of different liver cell types orchestrate the healing process.
Keywords
Spatial Transcriptomics
Spatial Temporal Transcriptomics
MeSH terms
Cell Proliferation
Gene Expression Profiling
Hepatocytes
Liver
Liver Regeneration
Organogenesis
Authors