Mapping the developing human immune system across organs.
IF: 63.714
Cited by: 85


Single-cell genomics studies have decoded the immune cell composition of several human prenatal organs but were limited in describing the developing immune system as a distributed network across tissues. We profiled nine prenatal tissues combining single-cell RNA sequencing, antigen-receptor sequencing, and spatial transcriptomics to reconstruct the developing human immune system. This revealed the late acquisition of immune-effector functions by myeloid and lymphoid cell subsets and the maturation of monocytes and T cells before peripheral tissue seeding. Moreover, we uncovered system-wide blood and immune cell development beyond primary hematopoietic organs, characterized human prenatal B1 cells, and shed light on the origin of unconventional T cells. Our atlas provides both valuable data resources and biological insights that will facilitate cell engineering, regenerative medicine, and disease understanding.


Spatial Transcriptomics

MeSH terms

Immune System
Organ Specificity
Single-Cell Analysis


Suo, Chenqu
Dann, Emma
Goh, Issac
Jardine, Laura
Kleshchevnikov, Vitalii
Park, Jong-Eun
Botting, Rachel A
Stephenson, Emily
Engelbert, Justin
Tuong, Zewen Kelvin
Polanski, Krzysztof
Yayon, Nadav
Xu, Chuan
Suchanek, Ondrej
Elmentaite, Rasa
Domínguez Conde, Cecilia
He, Peng
Pritchard, Sophie
Miah, Mohi
Moldovan, Corina
Steemers, Alexander S
Mazin, Pavel
Prete, Martin
Horsfall, Dave
Marioni, John C
Clatworthy, Menna R
Haniffa, Muzlifah
Teichmann, Sarah A

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