A high-resolution view of intra-tumoral B cell immunity.
Abstract
In this issue of Immunity, Meylan et al. (2022) uses spatial transcriptomics to examine B cell immunity within intratumoral tertiary lymphoid structures (TLSs). They find that B cells expand and mature into plasma cells (PCs) within the TLS, migrate along fibroblastic tracks to tumor beds, and produce IgG antibodies that target cancer cells.
Keywords
Spatial Transcriptomics
Authors
Recommend literature
1. Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing plasma cells in renal cell cancer.
2. B Cell Orchestration of Anti-tumor Immune Responses: A Matter of Cell Localization and Communication.
3. Comprehensive analysis of spatial architecture in primary liver cancer.