Control of tissue development and cell diversity by cell cycle-dependent transcriptional filtering.
IF: 8.713
Cited by: 3


Cell cycle duration changes dramatically during development, starting out fast to generate cells quickly and slowing down over time as the organism matures. The cell cycle can also act as a transcriptional filter to control the expression of long gene transcripts, which are partially transcribed in short cycles. Using mathematical simulations of cell proliferation, we identify an emergent property that this filter can act as a tuning knob to control gene transcript expression, cell diversity, and the number and proportion of different cell types in a tissue. Our predictions are supported by comparison to single-cell RNA-seq data captured over embryonic development. Additionally, evolutionary genome analysis shows that fast-developing organisms have a narrow genomic distribution of gene lengths while slower developers have an expanded number of long genes. Our results support the idea that cell cycle dynamics may be important across multicellular animals for controlling gene transcript expression and cell fate.


Gene Expression
cell cycle duration
computational biology
computational model
developmental biology
early development
fate decisions
systems biology
transcriptional filter

MeSH terms

Cell Cycle
Computer Simulation
Gene Expression Regulation, Developmental
Models, Biological
Single-Cell Analysis
Transcription, Genetic


Abou Chakra, Maria
Isserlin, Ruth
Tran, Thinh N
Bader, Gary D

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