Recent advances in single-cell multimodal analysis to study immune cells.
Abstract
Recent advances in single-cell technologies have enabled the profiling of the genome, epigenome, transcriptome and proteome, along with temporal and spatial information of individual cells. These technologies have provided unique opportunities to understand mechanisms underpinning the immune system, such as characterizations of the molecular cell state, how the cell state evolves along its lineage and the impact of spatial location on cell state. In this review, we discuss how these mechanisms have been studied through recent advances in single-cell multimodal technologies.
Keywords
smFISH
Spatial Transcriptomics
osmFISH
LCM-seq
cell state
cell-cell interaction
clonal analysis
immune cells
lineage
multimodal analysis
pseudotime
single-cell technology
temporal analysis
MeSH terms
Immune System
Proteome
Single-Cell Analysis
Transcriptome
Authors
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