Regional, Layer, and Cell-Type-Specific Connectivity of the Mouse Default Mode Network.
IF: 18.688
Cited by: 70


The evolutionarily conserved default mode network (DMN) is a distributed set of brain regions coactivated during resting states that is vulnerable to brain disorders. How disease affects the DMN is unknown, but detailed anatomical descriptions could provide clues. Mice offer an opportunity to investigate structural connectivity of the DMN across spatial scales with cell-type resolution. We co-registered maps from functional magnetic resonance imaging and axonal tracing experiments into the 3D Allen mouse brain reference atlas. We find that the mouse DMN consists of preferentially interconnected cortical regions. As a population, DMN layer 2/3 (L2/3) neurons project almost exclusively to other DMN regions, whereas L5 neurons project in and out of the DMN. In the retrosplenial cortex, a core DMN region, we identify two L5 projection types differentiated by in- or out-DMN targets, laminar position, and gene expression. These results provide a multi-scale description of the anatomical correlates of the mouse DMN.


Gene Expression
Default mode network
axonal projections
cortical connectome
projection neuron types
retrosplenial cortex
single cell transcriptomics
viral tracer

MeSH terms

Default Mode Network
Magnetic Resonance Imaging
Nerve Net


Whitesell, Jennifer D
Liska, Adam
Coletta, Ludovico
Hirokawa, Karla E
Bohn, Phillip
Williford, Ali
Groblewski, Peter A
Graddis, Nile
Kuan, Leonard
Knox, Joseph E
Ho, Anh
Wakeman, Wayne
Nicovich, Philip R
Nguyen, Thuc Nghi
van Velthoven, Cindy T J
Garren, Emma
Fong, Olivia
Naeemi, Maitham
Henry, Alex M
Dee, Nick
Smith, Kimberly A
Levi, Boaz
Feng, David
Ng, Lydia
Tasic, Bosiljka
Zeng, Hongkui
Mihalas, Stefan
Gozzi, Alessandro
Harris, Julie A

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