Roadmap for the multiscale coupling of biochemical and mechanical signals during development.
IF: 2.959
Cited by: 7


The way in which interactions between mechanics and biochemistry lead to the emergence of complex cell and tissue organization is an old question that has recently attracted renewed interest from biologists, physicists, mathematicians and computer scientists. Rapid advances in optical physics, microscopy and computational image analysis have greatly enhanced our ability to observe and quantify spatiotemporal patterns of signalling, force generation, deformation, and flow in living cells and tissues. Powerful new tools for genetic, biophysical and optogenetic manipulation are allowing us to perturb the underlying machinery that generates these patterns in increasingly sophisticated ways. Rapid advances in theory and computing have made it possible to construct predictive models that describe how cell and tissue organization and dynamics emerge from the local coupling of biochemistry and mechanics. Together, these advances have opened up a wealth of new opportunities to explore how mechanochemical patterning shapes organismal development. In this roadmap, we present a series of forward-looking case studies on mechanochemical patterning in development, written by scientists working at the interface between the physical and biological sciences, and covering a wide range of spatial and temporal scales, organisms, and modes of development. Together, these contributions highlight the many ways in which the dynamic coupling of mechanics and biochemistry shapes biological dynamics: from mechanoenzymes that sense force to tune their activity and motor output, to collectives of cells in tissues that flow and redistribute biochemical signals during development.


Spatial Transcriptomics
Spatial Temporal Transcriptomics

MeSH terms

Biomechanical Phenomena
Models, Biological
Signal Transduction


Lenne, Pierre-François
Munro, Edwin
Heemskerk, Idse
Warmflash, Aryeh
Bocanegra-Moreno, Laura
Kishi, Kasumi
Kicheva, Anna
Long, Yuchen
Fruleux, Antoine
Boudaoud, Arezki
Saunders, Timothy E
Caldarelli, Paolo
Michaut, Arthur
Gros, Jerome
Maroudas-Sacks, Yonit
Keren, Kinneret
Hannezo, Edouard
Gartner, Zev J
Stormo, Benjamin
Gladfelter, Amy
Rodrigues, Alan
Shyer, Amy
Minc, Nicolas
Maître, Jean-Léon
Di Talia, Stefano
Khamaisi, Bassma
Sprinzak, David
Tlili, Sham

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