MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations.
IF: 19.160
Cited by: 547


The mammalian mitochondrial proteome is under dual genomic control, with 99% of proteins encoded by the nuclear genome and 13 originating from the mitochondrial DNA (mtDNA). We previously developed MitoCarta, a catalogue of over 1000 genes encoding the mammalian mitochondrial proteome. This catalogue was compiled using a Bayesian integration of multiple sequence features and experimental datasets, notably protein mass spectrometry of mitochondria isolated from fourteen murine tissues. Here, we introduce MitoCarta3.0. Beginning with the MitoCarta2.0 inventory, we performed manual review to remove 100 genes and introduce 78 additional genes, arriving at an updated inventory of 1136 human genes. We now include manually curated annotations of sub-mitochondrial localization (matrix, inner membrane, intermembrane space, outer membrane) as well as assignment to 149 hierarchical 'MitoPathways' spanning seven broad functional categories relevant to mitochondria. MitoCarta3.0, including sub-mitochondrial localization and MitoPathway annotations, is freely available at and should serve as a continued community resource for mitochondrial biology and medicine.

MeSH terms

Bayes Theorem
DNA, Mitochondrial
Databases, Protein
Datasets as Topic
Machine Learning
Mass Spectrometry
Mitochondrial Membranes
Mitochondrial Proteins
Molecular Sequence Annotation


Rath, Sneha
Sharma, Rohit
Gupta, Rahul
Ast, Tslil
Chan, Connie
Durham, Timothy J
Goodman, Russell P
Grabarek, Zenon
Haas, Mary E
Hung, Wendy H W
Joshi, Pallavi R
Jourdain, Alexis A
Kim, Sharon H
Kotrys, Anna V
Lam, Stephanie S
McCoy, Jason G
Meisel, Joshua D
Miranda, Maria
Panda, Apekshya
Patgiri, Anupam
Rogers, Robert
Sadre, Shayan
Shah, Hardik
Skinner, Owen S
To, Tsz-Leung
Walker, Melissa A
Wang, Hong
Ward, Patrick S
Wengrod, Jordan
Yuan, Chen-Ching
Calvo, Sarah E
Mootha, Vamsi K

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