Sarcoma treatment in the era of molecular medicine.
IF: 14.260
Cited by: 101


Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers. Although constituting only 1% of all human malignancies, sarcomas represent the second most common type of solid tumors in children and adolescents and comprise an important group of secondary malignancies. More than 100 histological subtypes have been characterized to date, and many more are being discovered due to molecular profiling. Owing to their mostly aggressive biological behavior, relative rarity, and occurrence at virtually every anatomical site, many sarcoma subtypes are in particular difficult-to-treat categories. Current multimodal treatment concepts combine surgery, polychemotherapy (with/without local hyperthermia), irradiation, immunotherapy, and/or targeted therapeutics. Recent scientific advancements have enabled a more precise molecular characterization of sarcoma subtypes and revealed novel therapeutic targets and prognostic/predictive biomarkers. This review aims at providing a comprehensive overview of the latest advances in the molecular biology of sarcomas and their effects on clinical oncology; it is meant for a broad readership ranging from novices to experts in the field of sarcoma.


Spatial Transcriptomics
bone sarcoma
molecular diagnostics
molecular medicine
soft tissue sarcoma
targeted therapy

MeSH terms

Bone Neoplasms
Molecular Medicine
Soft Tissue Neoplasms


Grünewald, Thomas Gp
Alonso, Marta
Avnet, Sofia
Banito, Ana
Burdach, Stefan
Cidre-Aranaz, Florencia
Di Pompo, Gemma
Distel, Martin
Dorado-Garcia, Heathcliff
Garcia-Castro, Javier
González-González, Laura
Grigoriadis, Agamemnon E
Kasan, Merve
Koelsche, Christian
Krumbholz, Manuela
Lecanda, Fernando
Lemma, Silvia
Longo, Dario L
Madrigal-Esquivel, Claudia
Morales-Molina, Álvaro
Musa, Julian
Ohmura, Shunya
Ory, Benjamin
Pereira-Silva, Miguel
Perut, Francesca
Rodriguez, Rene
Seeling, Carolin
Al Shaaili, Nada
Shaabani, Shabnam
Shiavone, Kristina
Sinha, Snehadri
Tomazou, Eleni M
Trautmann, Marcel
Vela, Maria
Versleijen-Jonkers, Yvonne Mh
Visgauss, Julia
Zalacain, Marta
Schober, Sebastian J
Lissat, Andrej
English, William R
Baldini, Nicola
Heymann, Dominique

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