Temporal and Spatial Heterogeneity of Host Response to SARS-CoV-2 Pulmonary Infection.
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Cited by: 16


The relationship of SARS-CoV-2 lung infection and severity of pulmonary disease is not fully understood. We analyzed autopsy specimens from 24 patients who succumbed to SARS-CoV-2 infection using a combination of different RNA and protein analytical platforms to characterize inter- and intra- patient heterogeneity of pulmonary virus infection. There was a spectrum of high and low virus cases that was associated with duration of disease and activation of interferon pathway genes. Using a digital spatial profiling platform, the virus corresponded to distinct spatial expression of interferon response genes and immune checkpoint genes demonstrating the intra-pulmonary heterogeneity of SARS-CoV-2 infection.


Spatial Gene Expression
Spatial Transcriptomics


Desai, Niyati
Neyaz, Azfar
Szabolcs, Annamaria
Shih, Angela R
Chen, Jonathan H
Thapar, Vishal
Nieman, Linda T
Solovyov, Alexander
Mehta, Arnav
Lieb, David J
Kulkarni, Anupriya S
Jaicks, Christopher
Pinto, Christopher J
Juric, Dejan
Chebib, Ivan
Colvin, Robert B
Kim, Arthur Y
Monroe, Robert
Warren, Sarah E
Danaher, Patrick
Reeves, Jason W
Gong, Jingjing
Rueckert, Erroll H
Greenbaum, Benjamin D
Hacohen, Nir
Lagana, Stephen M
Rivera, Miguel N
Sholl, Lynette M
Stone, James R
Ting, David T
Deshpande, Vikram

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