Morphometric Cell Classification for Single-Cell MALDI-Mass Spectrometry Imaging.
Abstract
The large-scale and label-free molecular characterization of single cells in their natural tissue habitat remains a major challenge in molecular biology. We present a method that integrates morphometric image analysis to delineate and classify individual cells with their single-cell-specific molecular profiles. This approach provides a new means to study spatial biological processes such as cancer field effects and the relationship between morphometric and molecular features.
Keywords
imaging
lipids
mass spectrometry
morphometry
single-cell analysis
MeSH terms
Animals
Colon
Disease Models, Animal
Lipids
Single-Cell Analysis
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Stomach Neoplasms
Swine
Authors
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