Use of Single-Cell -Omic Technologies to Study the Gastrointestinal Tract and Diseases, From Single Cell Identities to Patient Features.
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IF: 33.883
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Cited by: 15
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Abstract

Single cells are the building blocks of tissue systems that determine organ phenotypes, behaviors, and functions. Understanding the differences between cell types and their activities might provide us with insights into normal tissue physiology, development of disease, and new therapeutic strategies. Although -omic level single-cell technologies are a relatively recent development that have been used only in research settings, these approaches might eventually be used in the clinic. We review the prospects of applying single-cell genome, transcriptome, epigenome, proteome, and metabolome analyses to gastroenterology and hepatology research. Combining data from multi-omic platforms coupled to rapid technological development could lead to new diagnostic, prognostic, and therapeutic approaches.

Keywords

seqFISH+
Omics
MERFISH
Seurat
SIMS
Spatial Transcriptomics
HDST
Gene Expression
Slide-seq
MALDI
SPLiT-seq
Epigenomics
Heterogeneity
Metabolomics
Proteomics

MeSH terms

Biomedical Research
Gastrointestinal Diseases
Gastrointestinal Tract
Gene Expression Profiling
Genomics
Humans
Metabolomics
Proteomics
Single-Cell Analysis

Authors

Islam, Mirazul
Chen, Bob
Spraggins, Jeffrey M
Kelly, Ryan T
Lau, Ken S

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