The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution.
IF: 66.850
Cited by: 266


Crucial transitions in cancer-including tumor initiation, local expansion, metastasis, and therapeutic resistance-involve complex interactions between cells within the dynamic tumor ecosystem. Transformative single-cell genomics technologies and spatial multiplex in situ methods now provide an opportunity to interrogate this complexity at unprecedented resolution. The Human Tumor Atlas Network (HTAN), part of the National Cancer Institute (NCI) Cancer Moonshot Initiative, will establish a clinical, experimental, computational, and organizational framework to generate informative and accessible three-dimensional atlases of cancer transitions for a diverse set of tumor types. This effort complements both ongoing efforts to map healthy organs and previous large-scale cancer genomics approaches focused on bulk sequencing at a single point in time. Generating single-cell, multiparametric, longitudinal atlases and integrating them with clinical outcomes should help identify novel predictive biomarkers and features as well as therapeutically relevant cell types, cell states, and cellular interactions across transitions. The resulting tumor atlases should have a profound impact on our understanding of cancer biology and have the potential to improve cancer detection, prevention, and therapeutic discovery for better precision-medicine treatments of cancer patients and those at risk for cancer.


Spatial reconstruction
Spatial Transcriptomics
Spatial Genomics
Cancer Moonshot
Human Tumor Atlas
cancer transitions
data integration
data visualization
single-cell genomics
spatial genomics
spatial imaging

MeSH terms

Atlases as Topic
Cell Transformation, Neoplastic
Precision Medicine
Single-Cell Analysis
Tumor Microenvironment


Rozenblatt-Rosen, Orit
Regev, Aviv
Oberdoerffer, Philipp
Nawy, Tal
Hupalowska, Anna
Rood, Jennifer E
Ashenberg, Orr
Cerami, Ethan
Coffey, Robert J
Demir, Emek
Ding, Li
Esplin, Edward D
Ford, James M
Goecks, Jeremy
Ghosh, Sharmistha
Gray, Joe W
Guinney, Justin
Hanlon, Sean E
Hughes, Shannon K
Hwang, E Shelley
Iacobuzio-Donahue, Christine A
Jané-Valbuena, Judit
Johnson, Bruce E
Lau, Ken S
Lively, Tracy
Mazzilli, Sarah A
Pe'er, Dana
Santagata, Sandro
Shalek, Alex K
Schapiro, Denis
Snyder, Michael P
Sorger, Peter K
Spira, Avrum E
Srivastava, Sudhir
Tan, Kai
West, Robert B
Williams, Elizabeth H

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