Expression and localization of DAB1 and Reelin during normal human kidney development.
IF: 2.415
Cited by: 7


To explore the spatial and temporal expression patterns of DAB1 and Reelin in the developing and postnatal healthy human kidneys as potential determinants of kidney development. Paraffin-embedded fetal kidney tissue between the 13/14th and 38th developmental weeks (dw) and postnatal tissue at 1.5 and 7 years were stained with DAB1 and Reelin antibodies by double immunofluorescence. During the fetal kidney development and postnatal period, DAB1 and Reelin showed specific spatial expression pattern and diverse fluorescence intensity. During the fetal period, DAB1 was strongly expressed in the distal convoluted tubules (DCT), with strong reactivity, and diversely in the proximal convoluted tubules (PCT) and glomeruli. In the postnatal period, DAB1 expression decreased. The strongest Reelin expression in early fetal stages was observed in the PCT. In the postnatal period, Reelin expression decreased dramatically in all observed structures. These two markers were colocalized during early developmental stages, mostly in PCT, DCT, and podocytes. The appearance of DAB1 and Reelin during fetal kidney development confirms their potential significant role in the formation of kidney structure or function. High DAB1 expression in the DCT implies its regulatory role in tubular formation or function maintenance during development. Reelin was highly expressed in human kidneys at early fetal stages, mostly in the PCT, while at later fetal stages and postnatal period its expression decreased.

MeSH terms

Adaptor Proteins, Signal Transducing
Cell Adhesion Molecules, Neuronal
Extracellular Matrix Proteins
Fetal Development
Gestational Age
Kidney Tubules, Distal
Kidney Tubules, Proximal
Nerve Tissue Proteins
Reelin Protein
Serine Endopeptidases


Racetin, Anita
Jurić, Marija
Filipović, Natalija
Šolić, Ivana
Kosović, Ivona
Glavina Durdov, Merica
Kunac, Nenad
Zekić Tomaš, Sandra
Saraga, Marijan
Šoljić, Violeta
Martinović, Vlatka
Petričević, Joško
Restović, Ivana
Lasić, Valentina
Kostić, Sandra
Kablar, Boris
Watanabe, Koichiro
Katsuyama, Yu
Saraga Babić, Mirna
Vukojević, Katarina

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