Polycomb Repressive Complex 1 Controls Maintenance of Fungiform Papillae by Repressing Sonic Hedgehog Expression.
IF: 9.995
Cited by: 9


How tissue patterns are formed and maintained are fundamental questions. The murine tongue epithelium, a paradigm for tissue patterning, consists of an array of specialized fungiform papillae structures that harbor taste cells. The formation of fungiform papillae is preceded by pronounced spatial changes in gene expression, in which taste cell genes such as Shh, initially diffused in lingual epithelial progenitors, become restricted to taste cells when their specification progresses. However, the requirement of spatial restriction of taste cell gene expression for patterning and formation of fungiform papillae is unknown. Here, we show that a chromatin regulator, Polycomb repressive complex (PRC) 1, is required for proper maintenance of fungiform papillae by repressing Shh and preventing ectopic SHH signaling in non-taste cells. Ablation of SHH signaling in PRC1-null non-taste cells rescues the maintenance of taste cells. Altogether, our studies exemplify how epigenetic regulation establishes spatial gene expression patterns necessary for specialized niche structures.


Spatial Gene Expression
Sonic Hedgehog
filiform papillae
fungiform papillae

MeSH terms

Body Patterning
Cell Cycle
Chromatin Immunoprecipitation
Chromatin Immunoprecipitation Sequencing
Cyclin-Dependent Kinase Inhibitor p16
Epigenesis, Genetic
Gene Expression Regulation, Developmental
Gene Ontology
Hedgehog Proteins
Mice, Knockout
Microscopy, Electron, Scanning
Polycomb Repressive Complex 1
Polycomb Repressive Complex 2
Signal Transduction
Taste Buds


Bar, Carmit
Cohen, Idan
Zhao, Dejian
Pothula, Venu
Litskevitch, Anna
Koseki, Haruhiko
Zheng, Deyou
Ezhkova, Elena

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