The Human Lung Cell Atlas: A High-Resolution Reference Map of the Human Lung in Health and Disease.
IF: 7.748
Cited by: 118


Lung disease accounts for every sixth death globally. Profiling the molecular state of all lung cell types in health and disease is currently revolutionizing the identification of disease mechanisms and will aid the design of novel diagnostic and personalized therapeutic regimens. Recent progress in high-throughput techniques for single-cell genomic and transcriptomic analyses has opened up new possibilities to study individual cells within a tissue, classify these into cell types, and characterize variations in their molecular profiles as a function of genetics, environment, cell-cell interactions, developmental processes, aging, or disease. Integration of these cell state definitions with spatial information allows the in-depth molecular description of cellular neighborhoods and tissue microenvironments, including the tissue resident structural and immune cells, the tissue matrix, and the microbiome. The Human Cell Atlas consortium aims to characterize all cells in the healthy human body and has prioritized lung tissue as one of the flagship projects. Here, we present the rationale, the approach, and the expected impact of a Human Lung Cell Atlas.


Spatial Transcriptomics
Human Cell Atlas
single-cell RNA sequencing
spatial transcriptomics
systems biology

MeSH terms

Lung Diseases


Schiller, Herbert B
Montoro, Daniel T
Simon, Lukas M
Rawlins, Emma L
Meyer, Kerstin B
Strunz, Maximilian
Vieira Braga, Felipe A
Timens, Wim
Koppelman, Gerard H
Budinger, G R Scott
Burgess, Janette K
Waghray, Avinash
van den Berge, Maarten
Theis, Fabian J
Regev, Aviv
Kaminski, Naftali
Rajagopal, Jayaraj
Teichmann, Sarah A
Misharin, Alexander V
Nawijn, Martijn C

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