Multidimensional Single-Cell Analyses in Organ Development and Maintenance.
Cited by: 7
The revolution of single-cell analysis tools in epigenomics, transcriptomics, lineage tracing, and transcriptome-scale RNA imaging, has boosted our understanding of the underlying molecular mechanisms during organ development and maintenance. Application of these tools enables the multidimensional study of organs, from cell atlas profiling, spatial organization, to cell-cell interaction. Here, we discuss recent progress in employing multidimensional single-cell analyses to address fundamental questions related to the development and maintenance of hematopoietic organs, brain and lung, which will also help provide insights into a better understanding of relevant diseases.
1. Computer vision for image-based transcriptomics.
2. Single cell transcriptomics: moving towards multi-omics.
3. The Secret Life of RNA: Lessons from Emerging Methodologies.
4. Brain transcriptome atlases: a computational perspective.
5. Contribution of Single-Cell Transcriptomics to the Characterization of Human Spermatogonial Stem Cells: Toward an Application in Male Fertility Regenerative Medicine?
1. Cell type atlas and lineage tree of a whole complex animal by single-cell transcriptomics
2. Simultaneous single-cell profiling of lineages and cell types in the vertebrate brain
3. Multi-modal analysis of the aging mouse lung at cellular resolution
4. Single cell transcriptome atlas of the Drosophila larval brain
5. Single cell RNA-seq of mouse brain vascular transcriptomes