Multidimensional Single-Cell Analyses in Organ Development and Maintenance.
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IF: 21.167
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Cited by: 7
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Abstract

The revolution of single-cell analysis tools in epigenomics, transcriptomics, lineage tracing, and transcriptome-scale RNA imaging, has boosted our understanding of the underlying molecular mechanisms during organ development and maintenance. Application of these tools enables the multidimensional study of organs, from cell atlas profiling, spatial organization, to cell-cell interaction. Here, we discuss recent progress in employing multidimensional single-cell analyses to address fundamental questions related to the development and maintenance of hematopoietic organs, brain and lung, which will also help provide insights into a better understanding of relevant diseases.

Keywords

Omics
MERFISH
Spatial Transcriptomics
smFISH
Spatial reconstruction
cell atlas
cell–cell interaction
organs
single-cell analysis
spatial organization

MeSH terms

Animals
Brain
Humans
Lung
Single-Cell Analysis

Authors

Zhang, Yifan
Liu, Feng

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