Transsynaptic interactions between IgSF proteins DIP-α and Dpr10 are required for motor neuron targeting specificity.
IF: 8.713
Cited by: 23


The Drosophila larval neuromuscular system provides an ideal context in which to study synaptic partner choice, because it contains a small number of pre- and postsynaptic cells connected in an invariant pattern. The discovery of interactions between two subfamilies of IgSF cell surface proteins, the Dprs and the DIPs, provided new candidates for cellular labels controlling synaptic specificity. Here we show that DIP-α is expressed by two identified motor neurons, while its binding partner Dpr10 is expressed by postsynaptic muscle targets. Removal of either DIP-α or Dpr10 results in loss of specific axonal branches and NMJs formed by one motor neuron, MNISN-1s, while other branches of the MNISN-1s axon develop normally. The temporal and spatial expression pattern of dpr10 correlates with muscle innervation by MNISN-1s during embryonic development. We propose a model whereby DIP-α and Dpr10 on opposing synaptic partners interact with each other to generate proper motor neuron connectivity.


Spatial Gene Expression
Cell-surface proteins
D. melanogaster
cell biology
muscle innervation
neuromuscular circuit
synaptic connectivity

MeSH terms

Drosophila Proteins
Drosophila melanogaster
Intercellular Signaling Peptides and Proteins
Membrane Proteins
Motor Neurons
Neuromuscular Junction
Neuronal Plasticity
Transcription Factors


Ashley, James
Sorrentino, Violet
Lobb-Rabe, Meike
Nagarkar-Jaiswal, Sonal
Tan, Liming
Xu, Shuwa
Xiao, Qi
Zinn, Kai
Carrillo, Robert A

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