Transcriptional Convergence of Oligodendrocyte Lineage Progenitors during Development.
IF: 13.417
Cited by: 118


Pdgfra+ oligodendrocyte precursor cells (OPCs) arise in distinct specification waves during embryogenesis in the central nervous system (CNS). It is unclear whether there is a correlation between these waves and different oligodendrocyte (OL) states at adult stages. Here, we present bulk and single-cell transcriptomics resources providing insights on how transitions between these states occur. We found that post-natal OPCs from brain and spinal cord present similar transcriptional signatures. Moreover, post-natal OPC progeny of E13.5 Pdgfra+ cells present electrophysiological and transcriptional profiles similar to OPCs derived from subsequent specification waves, indicating that Pdgfra+ pre-OPCs rewire their transcriptional network during development. Single-cell RNA-seq and lineage tracing indicates that a subset of E13.5 Pdgfra+ cells originates cells of the pericyte lineage. Thus, our results indicate that embryonic Pdgfra+ cells in the CNS give rise to distinct post-natal cell lineages, including OPCs with convergent transcriptional profiles in different CNS regions.


neural development
neural progenitors
oligodendrocyte precursor cell
platelet-derived growth factor receptor alpha
single-cell RNA-seq
transcription factors

MeSH terms

Cell Differentiation
Cell Lineage
Cell Proliferation
Cells, Cultured
Receptor, Platelet-Derived Growth Factor alpha
Spinal Cord
Stem Cells


Marques, Sueli
van Bruggen, David
Vanichkina, Darya Pavlovna
Floriddia, Elisa Mariagrazia
Munguba, Hermany
Väremo, Leif
Giacomello, Stefania
Falcão, Ana Mendanha
Meijer, Mandy
Björklund, Åsa Kristina
Hjerling-Leffler, Jens
Taft, Ryan James
Castelo-Branco, Gonçalo

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