The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.
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Although gene discovery in neuropsychiatric disorders, including autism spectrum disorder, intellectual disability, epilepsy, schizophrenia, and Tourette disorder, has accelerated, resulting in a large number of molecular clues, it has proven difficult to generate specific hypotheses without the corresponding datasets at the protein complex and functional pathway level. Here, we describe one path forward-an initiative aimed at mapping the physical and genetic interaction networks of these conditions and then using these maps to connect the genomic data to neurobiology and, ultimately, the clinic. These efforts will include a team of geneticists, structural biologists, neurobiologists, systems biologists, and clinicians, leveraging a wide array of experimental approaches and creating a collaborative infrastructure necessary for long-term investigation. This initiative will ultimately intersect with parallel studies that focus on other diseases, as there is a significant overlap with genes implicated in cancer, infectious disease, and congenital heart defects.


neurodevelopmental disorder
psychiatric cell map initiative
psychiatric disorder
systems biology

MeSH terms

Chromosome Mapping
Gene Regulatory Networks
Genetic Predisposition to Disease
Genome-Wide Association Study
Neurodevelopmental Disorders
Systems Biology


Willsey, A Jeremy
Morris, Montana T
Wang, Sheng
Willsey, Helen R
Sun, Nawei
Teerikorpi, Nia
Baum, Tierney B
Cagney, Gerard
Bender, Kevin J
Desai, Tejal A
Srivastava, Deepak
Davis, Graeme W
Doudna, Jennifer
Chang, Edward
Sohal, Vikaas
Lowenstein, Daniel H
Li, Hao
Agard, David
Keiser, Michael J
Shoichet, Brian
von Zastrow, Mark
Mucke, Lennart
Finkbeiner, Steven
Gan, Li
Sestan, Nenad
Ward, Michael E
Huttenhain, Ruth
Nowakowski, Tomasz J
Bellen, Hugo J
Frank, Loren M
Khokha, Mustafa K
Lifton, Richard P
Kampmann, Martin
Ideker, Trey
State, Matthew W
Krogan, Nevan J

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