SpatialDE: identification of spatially variable genes.
Abstract
Technological advances have made it possible to measure spatially resolved gene expression at high throughput. However, methods to analyze these data are not established. Here we describe SpatialDE, a statistical test to identify genes with spatial patterns of expression variation from multiplexed imaging or spatial RNA-sequencing data. SpatialDE also implements 'automatic expression histology', a spatial gene-clustering approach that enables expression-based tissue histology.
Keywords
Spatial Gene Expression
Seurat
MeSH terms
Breast Neoplasms
Female
Gene Expression Regulation, Neoplastic
Humans
Models, Biological
Protein Transport
Single-Cell Analysis
Authors
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