PHD in the FOXD1 lineage cells links hypoxia to inappropriate nephrogenesis.
Insufficient oxygenation during pregnancy negatively influences kidney development, which likely serves as a predisposing factor in chronic kidney disease at later stages in life. In this issue of Kidney International, Kobayashi et al. demonstrate that deletion of prolyl hydroxylase 2 and 3, 2 of the major oxygen sensors, in the FoxD1 lineage cells reduces kidney size and inhibits nephrogenesis in mice. Temporospatial expression pattern and studies on additional knockouts suggest the involvement of hypoxia-inducible factor 2.
Spatial Gene Expression
Forkhead Transcription Factors
Hypoxia-Inducible Factor 1, alpha Subunit
Hypoxia-Inducible Factor-Proline Dioxygenases
1. Improving our resolution of kidney morphogenesis across time and space.
2. Role of Macrophages and Related Cytokines in Kidney Disease.
3. Decoding myofibroblast origins in human kidney fibrosis.
4. Myeloid Heterogeneity in Kidney Disease as Revealed through Single-Cell RNA Sequencing.
5. Quantitative Large-Scale Three-Dimensional Imaging of Human Kidney Biopsies: A Bridge to Precision Medicine in Kidney Disease.