4D nucleomes in single cells: what can computational modeling reveal about spatial chromatin conformation?
Abstract
Genome-wide sequencing technologies enable investigations of the structural properties of the genome in various spatial dimensions. Here, we review computational techniques developed to model the three-dimensional genome in single cells versus ensembles of cells and assess their underlying assumptions. We further address approaches to study the spatio-temporal aspects of genome organization from single-cell data.
MeSH terms
Algorithms
Computational Biology
Models, Molecular
Nucleic Acid Conformation
Nucleosomes
Single-Cell Analysis
Spatial Analysis
Authors
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