Adult mouse cortical cell taxonomy revealed by single cell transcriptomics.
|
IF: 28.771
|
Cited by: 1,353
|
Abstract
Nervous systems are composed of various cell types, but the extent of cell type diversity is poorly understood. We constructed a cellular taxonomy of one cortical region, primary visual cortex, in adult mice on the basis of single-cell RNA sequencing. We identified 49 transcriptomic cell types, including 23 GABAergic, 19 glutamatergic and 7 non-neuronal types. We also analyzed cell type-specific mRNA processing and characterized genetic access to these transcriptomic types by many transgenic Cre lines. Finally, we found that some of our transcriptomic cell types displayed specific and differential electrophysiological and axon projection properties, thereby confirming that the single-cell transcriptomic signatures can be associated with specific cellular properties.
Recommend literature
1. Brain structure. Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq.
2. Molecular Architecture of the Mouse Nervous System.
3. A transcriptomic and epigenomic cell atlas of the mouse primary motor cortex.
4. GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits.
5. Genome-wide atlas of gene expression in the adult mouse brain.
Similar data
1. Adult mouse cortical cell taxonomy by single cell transcriptomics
2. RNA-Seq of single cells from the mouse lumbar dorsal root ganglion
3. Massively parallel single-cell RNA-Seq for dissecting cell type and cell state compositions
4. A Transcriptomic Atlas of Mouse Neocortical Layers
5. An RNA-Seq transcriptome and splicing database of neurons, glia, and vascular cells of the cerebral cortex
