MERFISHing for spatial context.
Abstract
A new paper in Science by Zhuang and colleagues introduces multiplexed error-robust FISH (MERFISH). MERFISH extends single-molecule imaging techniques to profile the copy number and localization patterns of thousands of genes, representing a major advance for spatial transcriptomics, with exciting potential applications in immunology.
Keywords
Spatial Transcriptomics
MERFISH
MeSH terms
Gene Expression Profiling
Humans
In Situ Hybridization, Fluorescence
Molecular Imaging
RNA, Messenger
Single-Cell Analysis
Transcriptome
Authors
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