High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population.
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Cited by: 136


The functional unit of the kidney is the nephron. During its organogenesis, the mammalian metanephric kidney generates thousands of nephrons over a protracted period of fetal life. All nephrons are derived from a population of self-renewing multi-potent progenitor cells, termed the cap mesenchyme. However, our understanding of the molecular and cellular mechanisms underlying nephron development is at an early stage. In order to identify factors involved in nephrogenesis, we performed a high-resolution, spatial profiling of a number of transcriptional regulators expressed within the cap mesenchyme and early developing nephron. Our results demonstrate novel, stereotypic, spatially defined cellular sub-domains within the cap mesenchyme, which may, in part, reflect induction of nephron precursors. These results suggest a hitherto unappreciated complexity of cell states that accompany the assembly of the metanephric kidney, likely reflecting diverse regulatory actions such as the maintenance and induction of nephron progenitors.


Gene Expression

MeSH terms

Gene Expression Profiling
Gene Expression Regulation, Developmental
In Situ Hybridization
Microscopy, Fluorescence
Models, Biological
Protein Structure, Tertiary
Signal Transduction
Stem Cells
Time Factors
Transcription Factors
Wnt Proteins


Mugford, Joshua W
Yu, Jing
Kobayashi, Akio
McMahon, Andrew P

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