Blufensin1 negatively impacts basal defense in response to barley powdery mildew.
IF: 8.005
Cited by: 54


Plants have evolved complex regulatory mechanisms to control the defense response against microbial attack. Both temporal and spatial gene expression are tightly regulated in response to pathogen ingress, modulating both positive and negative control of defense. BLUFENSIN1 (BLN1), a small peptide belonging to a novel family of proteins in barley (Hordeum vulgare), is highly induced by attack from the obligate biotrophic fungus Blumeria graminis f. sp. hordei (Bgh), casual agent of powdery mildew disease. Computational interrogation of the Bln1 gene family determined that members reside solely in the BEP clade of the Poaceae family, specifically, barley, rice (Oryza sativa), and wheat (Triticum aestivum). Barley stripe mosaic virus-induced gene silencing of Bln1 enhanced plant resistance in compatible interactions, regardless of the presence or absence of functional Mla coiled-coil, nucleotide-binding site, Leu-rich repeat alleles, indicating that BLN1 can function in an R-gene-independent manner. Likewise, transient overexpression of Bln1 significantly increased accessibility toward virulent Bgh. Moreover, silencing in plants harboring the Mlo susceptibility factor decreased accessibility to Bgh, suggesting that BLN1 functions in parallel with or upstream of MLO to modulate penetration resistance. Collectively, these data suggest that the grass-specific Bln1 negatively impacts basal defense against Bgh.

MeSH terms

Amino Acid Sequence
Gene Expression Profiling
Gene Expression Regulation, Plant
Gene Silencing
Genes, Plant
Molecular Sequence Data
Multigene Family
Oligonucleotide Array Sequence Analysis
Plant Diseases
Plant Proteins
Plants, Genetically Modified
Promoter Regions, Genetic
RNA, Plant
Sequence Alignment


Meng, Yan
Moscou, Matthew J
Wise, Roger P

Recommend literature

Similar data