Establishment of developmental precision and proportions in the early Drosophila embryo.
IF: 69.504
Cited by: 409


During embryonic development, orderly patterns of gene expression eventually assign each cell in the embryo its particular fate. For the anteroposterior axis of the Drosophila embryo, the first step in this process depends on a spatial gradient of the maternal morphogen Bicoid (Bcd). Positional information of this gradient is transmitted to downstream gap genes, each occupying a well defined spatial domain. We determined the precision of the initial process by comparing expression domains in different embryos. Here we show that the Bcd gradient displays a high embryo-to-embryo variability, but that this noise in the positional information is strongly decreased ('filtered') at the level of hunchback (hb) gene expression. In contrast to the Bcd gradient, the hb expression pattern already includes the information about the scale of the embryo. We show that genes known to interact directly with Hb are not responsible for its spatial precision, but that the maternal gene staufen may be crucial.


Gene Expression

MeSH terms

Body Patterning
DNA-Binding Proteins
Drosophila Proteins
Drosophila melanogaster
Embryo, Nonmammalian
Embryonic Induction
Gene Expression Regulation, Developmental
Homeodomain Proteins
RNA-Binding Proteins
Transcription Factors


Houchmandzadeh, Bahram
Wieschaus, Eric
Leibler, Stanislas

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