Integrating Single-Cell RNA Sequencing and Spatial Transcriptomics to Map DEGs in AD Across Key Brain Regions
IDSTT0000099(Source: STOmics DB)
STOmics technology:BGI Stereomics Stereo-Seq
Organism(s):
Homo sapiens
Data type:Spatial transcriptomics
Sample scope:Other
Summary:In Alzheimer's disease (AD) research, understanding the spatial distribution of differentially expressed genes (DEGs) within key brain regions is crucial for elucidating disease mechanisms and identifying potential therapeutic targets. In this study, we utilized physiological group chips to integrate single-cell RNA sequencing (scRNA-seq) data with spatial transcriptomics to map DEGs in two critical brain regions: the dorsolateral prefrontal cortex (DLPFC) and the superior temporal gyrus (STG). By combining these advanced technologies, we aimed to observe the spatial arrangement of DEGs in cortical slices, providing insights into the cellular and molecular landscape of AD progression.
Contributor(s):Songren Wei, Jiangping Xu.
Publication(s):
  • Songren Wei, Jiangping Xu. Integrating Single-Cell RNA Sequencing and Spatial Transcriptomics to Map Differentially Expressed Genes in Alzheimer's Disease Across Key Brain Regions.
Submitter:韦淞仁(Songren Wei),Southern Medical University
Release date:2024-08-07
Updated:2024-08-29
Statistics:
  • Sample: 2
  • Tissue Section: 2
  • Experiment: 8
  • Run: 8
Datasize:1.07TB
Sequencing Data
Spatial Gene Expression
ProjectSampleTissue SectionExperimentRunOrganismPlatformSequencing readsMask file