An Organ-wide Spatiotemporal Transcriptomic and Cellular Atlas of the Regenerating Zebrafish Heart
IDSTT0000071(Source: STOmics DB)
STOmics technology:BGI Stereomics Stereo-Seq
Organism(s):
Data type:Spatial transcriptomics
Sample scope:Multiisolate
Summary:Adult zebrafish robustly regenerate injured hearts through a complex orchestration of cells and molecules. However, the comprehensive process remains incompletely understood. Here, we utilized single-cell RNA-sequencing (scRNA-seq) and Stereo-seq approaches to generate a spatially-resolved cell dataset of regenerating zebrafish heart. We captured organ-scale cellular dynamics across eight time points, with a particular focus on the initiative stages. We reconstructed a 4D "virtual regenerating heart" atlas, encompassing 3 spatial dimensions and time, comprising a total of 569,896 cells/spots derived from 36 scRNA-seq libraries and 224 Stereo-seq slices.
Contributor(s):Lei Li, Meina Lu, Lidong Guo, Xuejiao Zhang, Qun Liu et al.
Publication(s):
- Lei Li, Meina Lu, Lidong Guo, Xuejiao Zhang, Qun Liu et al. An Organ-wide Spatiotemporal Transcriptomic Atlas of Regenerating Zebrafish Heart.
Submitter:郭立东(Lidong Guo),BGI
Release date:2024-01-15
Updated:2025-01-22
Relations:
Statistics:
- Sample: 9
- Tissue Section: 46
Datasize:5.69GB
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