Fate Determination of Cancer-associated Fibroblast Drives Polarized Immunity in Cancer-stroma Boundary
IDSTT0000036(Source: STOmics DB)
STOmics technology:BGI Stereomics Stereo-Seq
Organism(s):
Homo sapiens
Data type:Transcriptome or Gene expression, Spatial transcriptomics
Sample scope:Multiisolate
Summary:The exciting responding rate to anti-PD1 treatment makes dMMR colorectal cancer (CRC) an outstanding model to explore the mechanism underlying immunotherapy sensitivity. This study provides a spatial transcriptomic landscape of CRC tumor at 50 μm resolution and highlights the plasticity of the cancer-stroma boundary immunity. It demonstrates the utility of high-resolution spatial transcriptome to study the cellular components and molecular pattern in the microscopic boundary, in which cancer cells co-opt stromal cells to alter the boundary immunity.
Contributor(s):Yu FENG, Yupeng ZANG, Wenjuan MA, Miaoqing WU, Gong CHEN et al.
Publication(s):
  • Yu FENG, Yupeng ZANG, Wenjuan MA, Miaoqing WU, Gong CHEN et al. Fate Determination of Cancer-associated Fibroblast Drives Polarized Immunity in Cancer-stroma Boundary.
Submitter:Yu Feng(Yu Feng),华大生命科学研究院
Release date:2024-04-10
Updated:2024-12-04
Statistics:
  • Sample: 16
  • Tissue Section: 16
Datasize:2.01GB
Spatial Gene Expression
ProjectSampleTissue SectionOrganismFiles