STOmics technology:BGI Stereomics Stereo-Seq

Data type:Spatial transcriptomics

Sample scope:Multispecies

Summary:Hypoxia is an important physiological stress causing organ injuries and diseases, but 30 its cellular and olecular impacts across organs were not fully understood. We constructed a single-cell spatiotemporal transcriptome atlas of hypoxia, with 350,979 cells from 99 cell clusters. Utilizing this atlas, we depicted hypoxia induced common cell changes including increase of erythroid cells and drastic changes of immune cells. And we found three major gene groups responding to hypoxia, including hypoxia-inducible factors (HIFs), hemoglobin genes, 35 and electron transport chain (ETC) genes. We also found many disease risk genes to be differentially expressed in multiple organs during hypoxia. Finally, we found a hypoxia induced novel cell type in the spleen, defined as erythroid-derived immunoregulatory cells (EDICs). Our dataset and analysis provided new insights into molecular mechanisms and physiological consequences of hypoxia.

Contributor(s):YUE WANG.

Submitter:王岳(Yue Wang),BGI

Release date:2024-09-21

Updated:2024-09-21