Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging(Dataset ID: STDS0000247)

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Dataset information
Summary:
To systematically characterize the loss of tissue integrity and organ dysfunction resulting from aging, we produced an in-depth spatial transcriptomic profile of nine tissues in male mice during aging. We showed that senescence-sensitive spots (SSSs) colocalized with elevated entropy in organizational structure and that the aggregation of immunoglobulin-expressing cells is a characteristic feature of the microenvironment surrounding SSSs. Immunoglobulin G (IgG) accumulated across the aged tissues in both male and female mice, and a similar phenomenon was observed in human tissues, suggesting the potential of the abnormal elevation of immunoglobulins as an evolutionarily conserved feature in aging. Furthermore, we observed that IgG could induce a pro-senescent state in macrophages and microglia, thereby exacerbating tissue aging, and that targeted reduction of IgG mitigated aging across various tissues in male mice. This study provides a high-resolution spatial depiction of aging and indicates the pivotal role of immunoglobulin-associated senescence during the aging process.
Technology:
Stereo-seq
Platform:
DNBSEQ-T1
Species:
Mus musculus
Tissues:
Spleen | Testis | Heart | Hippocampus | Small intestine | Liver | Lung | Lymph node | Spinal cord
Development stage:
Young | Old
Sex:
Male
Submission date: 2024-11-07Update date: 2024-11-07

Contributors
Yuzhe Sun
Contact: sunyuzhe@genomics.cn

Accessions
STOmicsDB Project ID: STT0000039

Reference way
Citation: Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging. Cell. 2024 Nov 2:S0092-8674(24)01201-7. doi: 10.1016/j.cell.2024.10.019. Epub ahead of print. PMID: 39500323.