Macaque Brain Atlas
Dataset ID: STDS0000140
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PMID:36347848
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Summary:
Non-human primates provide a unique way to study the only model in which both developmental and pathological features of the brain in a species phylogenetically close to human. In the past decade, breakthrough advances in single-cell sequencing have enabled the mapping of cell taxonomy and heterogeneity in the developing and adult brain of different mammalian species. Here, we generated single-cell chromatin accessibility (single-cell ATAC) and transcriptomic data of 358,237 cells from three cortical regions of the adult cynomolgus monkey Macaca fascicularis brain. We then integrated this dataset with Stereo-seq (Spatio-Temporal Enhanced Resolution Omics-sequencing) of the corresponding cortical areas to assign topographic information to molecular and regulatory states.
Technology:
Stereo-Seq
Platform:
DNBSEQ-T10
Species:
Macaca fascicularis(macFas5)
Tissues:
Brain
Citation:
Lei, Ying et al. “Spatially resolved gene regulatory and disease-related vulnerability map of the adult Macaque cortex.” Nature communications vol. 13,1 6747. 8 Nov. 2022, doi:10.1038/s41467-022-34413-3
Submission date: 2021-12-16Update date: 2021-12-16
Sample number: 1Section number: 3
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