Macaque Brain Atlas
Summary:Non-human primates provide a unique way to study the only model in which both developmental and pathological features of the brain in a species phylogenetically close to human. In the past decade, breakthrough advances in single-cell sequencing have enabled the mapping of cell taxonomy and heterogeneity in the developing and adult brain of different mammalian species. Here, we generated single-cell chromatin accessibility (single-cell ATAC) and transcriptomic data of 358,237 cells from three cortical regions of the adult cynomolgus monkey Macaca fascicularis brain. We then integrated this dataset with Stereo-seq (Spatio-Temporal Enhanced Resolution Omics-sequencing) of the corresponding cortical areas to assign topographic information to molecular and regulatory states.
Citation:Lei, Ying et al. “Spatially resolved gene regulatory and disease-related vulnerability map of the adult Macaque cortex.” Nature communications vol. 13,1 6747. 8 Nov. 2022, doi:10.1038/s41467-022-34413-3
Submission date: 2021-12-16Update date: 2021-12-16
Sample number: 1Section number: 3
CNGB Project: CNP0000927
Publication: Spatially resolved gene regulatory and disease-related vulnerability map of the adult Macaque cortex