Spatial transcriptome analysis defines heme as a hemopexin-targetable inflammatoxin in the brain
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Dataset information
Summary
After intracranial hemorrhages, heme is released from cell-free hemoglobin. This red blood cell toxin may drive secondary brain injury at the hematoma-brain interface. This study aimed to generate a spatially resolved map of the transcriptome-wide gene expression changes in the heme-exposed brain and define the potential therapeutic activity of the heme-binding protein hemopexin.
After intracranial hemorrhages, heme is released from cell-free hemoglobin. This red blood cell toxin may drive secondary brain injury at the hematoma-brain interface. This study aimed to generate a spatially resolved map of the transcriptome-wide gene expression changes in the heme-exposed brain and define the potential therapeutic activity of the heme-binding protein hemopexin.
Overall design
Spatial transcriptome analysis of mouse brain using the 10X genomics Visium spatial gene expression kit after stereotactic injections.
Spatial transcriptome analysis of mouse brain using the 10X genomics Visium spatial gene expression kit after stereotactic injections.
Technology
10x Visium
10x Visium
Platform
GPL24247
GPL24247
Species
Mus musculus
Tissues
Coronal Brain section
Coronal Brain section
Sex
Male
Male
Citation
Buzzi, Raphael M et al. Spatial transcriptome analysis defines heme as a hemopexin-targetable inflammatoxin in the brain.Free Radic Biol Med. 2022 Feb 1;179:277-287. doi: 10.1016/j.freeradbiomed.2021.11.011. Epub 2021 Nov 16.
Buzzi, Raphael M et al. Spatial transcriptome analysis defines heme as a hemopexin-targetable inflammatoxin in the brain.Free Radic Biol Med. 2022 Feb 1;179:277-287. doi: 10.1016/j.freeradbiomed.2021.11.011. Epub 2021 Nov 16.
Submission date: 2021-08-14Update date: 2021-12-29
Sample number: 7
Contributors
Buzzi, Raphael M; Akeret, Kevin; Hugelshofer, Michael; Schaer, Dominik J
Contact: [email protected]
Accessions
GEO Series Accessions:
GSE182127