Spatial transcriptome analysis defines heme as a hemopexin-targetable inflammatoxin in the brain
Dataset ID: STDS0000119
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PMID:34793930
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19,066 Spots
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26,124 Genes
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Dataset information
Summary:
After intracranial hemorrhages, heme is released from cell-free hemoglobin. This red blood cell toxin may drive secondary brain injury at the hematoma-brain interface. This study aimed to generate a spatially resolved map of the transcriptome-wide gene expression changes in the heme-exposed brain and define the potential therapeutic activity of the heme-binding protein hemopexin.
Overall design:
Spatial transcriptome analysis of mouse brain using the 10X genomics Visium spatial gene expression kit after stereotactic injections.
Technology:
10x Visium
Platform:
GPL24247
Species:
Mus musculus(mm10)
Tissues:
Brain
Organ parts:
Coronal Brain
Sex:
Male
Citation:
Buzzi, Raphael M et al. “Spatial transcriptome analysis defines heme as a hemopexin-targetable inflammatoxin in the brain.” Free radical biology & medicine vol. 179 (2022): 277-287. doi:10.1016/j.freeradbiomed.2021.11.011
Submission date: 2021-08-14Update date: 2021-12-29
Sample number: 7
Contributors
Buzzi, Raphael M; Akeret, Kevin; Hugelshofer, Michael; Schaer, Dominik J
Contact: raphael.buzzi@usz.ch
Accessions
GEO Series Accessions: GSE182127