Spatial transcriptome analysis defines heme as a hemopexin-targetable inflammatoxin in the brain(Dataset ID: STDS0000119)

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514
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752
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Spots: 19,066
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Genes: 26,124
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PMID: 34793930
Summary
Visualization
Data
Analysis results
Related
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Dataset information
Contributors
Accessions
How to cite
Dataset information
Summary:
After intracranial hemorrhages, heme is released from cell-free hemoglobin. This red blood cell toxin may drive secondary brain injury at the hematoma-brain interface. This study aimed to generate a spatially resolved map of the transcriptome-wide gene expression changes in the heme-exposed brain and define the potential therapeutic activity of the heme-binding protein hemopexin.
Overall design:
Spatial transcriptome analysis of mouse brain using the 10X genomics Visium spatial gene expression kit after stereotactic injections.
Technology:
10x Visium
Platform:
GPL24247
Species:
Mus musculus(mm10)
Tissues:
Brain
Organ parts:
Coronal Brain
Sex:
Male
Submission date: 2021-08-14Update date: 2021-12-29
Sample number: 7
DOI: To be continue
Contributors
Buzzi, Raphael M,Akeret, Kevin,Hugelshofer, Michael,Schaer, Dominik J
Contact: raphael.buzzi@usz.ch
Accessions
GEO Series Accessions: GSE182127
How to cite
  • Cite database of STOmicsDB:
    [1] Xu, Zhicheng et al. "STOmicsDB: a comprehensive database for spatial transcriptomics data sharing, analysis and visualization." Nucleic acids research vol. 52,D1 (2024): D1053-D1061. doi: 10.1093/nar/gkad933'
  • Cite visualization dataset:
    [2] Buzzi, Raphael M,Akeret, Kevin,Hugelshofer, Michael,Schaer, Dominik J. Spatial transcriptome analysis defines heme as a hemopexin-targetable inflammatoxin in the brain[DS/OL]. STOmicsDB, 2021[2021-08-14]. https://db.cngb.org/stomics/datasets/STDS0000119/. doi: xxxxxx
    #Format: {contributors}. {title}[DS/OL]. STOmicsDB, {the year of submission data}[{submission data}]. {dataset link}. doi: {doi ID}
  • Cite original data article:
    Citation: Buzzi, Raphael M et al. “Spatial transcriptome analysis defines heme as a hemopexin-targetable inflammatoxin in the brain.” Free radical biology & medicine vol. 179 (2022): 277-287. doi:10.1016/j.freeradbiomed.2021.11.011