Spatiotemporal role of the lncRNA Evx1as in embryonic patterning(Dataset ID: STDS0000095)

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PMID: 29420831
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Dataset information
Summary:
We performed spatial transcriptome analysis on cryosections of gastrulating embryos from E6.5 to E7.5 by low-input RNA sequencing (Geo-seq). Careful spatial transcriptomic analysis revealed that the lncRNA Evx1as plays a transient spatiotemporal role in regulating embryonic patterning during gastrulation, yet is dispensable for overall development and survival. Altogether, these results suggest that many lncRNAs are generally dispensable for normal development and survival, but may be selectively required in a particular context in vivo.
Overall design:
All RNA-seq(s) were designed to reveal the spatiotemporal role of lncRNA Evx1as in embryonic patterning.
Technology:
Geo-seq
Platform:
GPL17021
Species:
Mus musculus(mm10)
Cell types:
embryonic stem cells,4x polyA KI in embryonic stem cells,Evx1as+/- proximal posterier,Evx1as+/- dist
Development stage:
Embryonic 7 days
Submission date: 2017-09-26Update date: 2021-07-25
DOI: To be continue
Contributors
Luo S,Peng G,Cui G,Lu J,Jing N,Shen X
Contact: bioyuyang@hotmail.com
Accessions
GEO Series Accessions: GSE104292
How to cite
  • Cite database of STOmicsDB:
    [1] Xu, Zhicheng et al. "STOmicsDB: a comprehensive database for spatial transcriptomics data sharing, analysis and visualization." Nucleic acids research vol. 52,D1 (2024): D1053-D1061. doi: 10.1093/nar/gkad933'
  • Cite visualization dataset:
    [2] Luo S,Peng G,Cui G,Lu J,Jing N,Shen X. Spatiotemporal role of the lncRNA Evx1as in embryonic patterning[DS/OL]. STOmicsDB, 2017[2017-09-26]. https://db.cngb.org/stomics/datasets/STDS0000095/. doi: xxxxxx
    #Format: {contributors}. {title}[DS/OL]. STOmicsDB, {the year of submission data}[{submission data}]. {dataset link}. doi: {doi ID}
  • Cite original data article:
    Citation: Han, Xue et al. “Mouse knockout models reveal largely dispensable but context-dependent functions of lncRNAs during development.” Journal of molecular cell biology vol. 10,2 (2018): 175-178. doi:10.1093/jmcb/mjy003